Publication processes organization and format errata, author corrections, retractions. The ability to crosspresent has been thought of as a feature of specialized dc subsets. Receptors and crosspresentation in dendritic cells journal of. In vivo, crosspresentation is mainly carried out by specific dendritic cell dc subsets through an.
Dcs are especially known for their ability to crosspresent, as they process and present exogenous antigens on mhci molecules much more efficiently than other phagocytes. Current concepts of antigen crosspresentation ncbi. Adjuvants enhancing crosspresentation by dendritic cells frontiers. Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen crosspresentation and. Pdf crosspresentation by dendritic cells researchgate. In vivo, cross presentation is mainly carried out by specific dendritic cell dc subsets through an. Antigen crosspresentation describes the process through which dendritic cells dcs acquire exogenous antigens for presentation on mhc class i molecules.
Adjuvants enhancing crosspresentation by dendritic cells. The primary and most efficient crosspresenting cells are dendritic cells, though. Dendritic cells are the professional apcs of our immune system that are key in. Limited proteolysis in the endocytic compartments of dendritic cells dcs favours crosspresentation by preventing the destruction of internalized antigens. Two human immunodeficiency virus vaccinal lipopeptides follow. Dendritic cells dcs have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can. Targeting uptake receptors on human plasmacytoid dendritic. Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex mhc i molecules. Crosspresentation of cellassociated antigens by mhc. Antigen crosspresentation by dendritic cell subsets. In vivo, crosspresentation is mainly carried out by specific dendritic cell dc subsets through an adaptation of their endocytic and phagocytic pathways. Crosspresentation is the ability of certain antigenpresenting cells to take up, process and. Crosspresentation by dendritic cells 491 internalized into cells of the dc lineage either through cd4 and the coreceptors ccr5 or cxcr4, but also through dcsign for interstitial. In the cytosolic pathway, exogenous antigens are translocated from endosomal compartments into the cytosol for degradation by the proteasome.
Plasmacytoid dendritic cells pdcs play a crucial role in initiating immune responses by secreting large amounts of type i ifns. Molecular mechanisms of dendritic cell crosspresentation dendritic cells are the professional apcs of our immune system that are key in linking innate and adaptive immunity. Dendritic cellmediated antigen presentation initiates specific immune responses. Thesestudiessupporttheviewthat, under certain circumstances, speci. Molecular mechanisms of dendritic cell crosspresentation. What links here related changes upload file special pages permanent link page information. However, cross presentation by dc of exogenous antigens on class i.